The PULS Cardiac Test is a blood test that recognizes the asymptomatic “susceptible patient” by measuring endothelial injury, anticipating Acute Coronary Syndrome (ACS), and enhancing patient care. The PULS Test assesses the most clinically relevant biomarkers of proteins that measure the response of the body's immune system to arterial damage. These injuries contribute to the development and progression of dysfunctional and ruptured cardiac lesions, leading to cardiac events.

The PULS Test evaluates 9 clinically important protein biomarkers triggered by the body's immune response to endothelial dysfunction. In a 5-year timespan, these variables are measured into a single score that estimates ACS. From this metric, doctors can take steps to prevent the progression of the disease and provide guidance to improve patient care.

Unstable Cardiac Lesions form inside the artery wall over a period, often with no signs or symptoms, through a system of continuous arterial damage and repair. When oxidized or weakened lipids bind and accumulate on the arterial surface, an unstable lesion starts to form, triggering an injury. The method activates molecules that draw white blood cells like eosinophils, monocytes, T-cells, and granulocytes, to the arterial wall.

The endothelium (or endothelial layer) is the inner lining of cells and performs various critical functions. Its proper functioning is crucial for the usual function of the body’s organs and tissues. Endothelial dysfunction/damage is a form of non-disruptive coronary artery disease (CAD). In such cases, there are no blockages of the heart artery, but instead of opening, the large blood vessels on the surface of the heart contracts. In such a condition, the small arteries fail to carry out their significant functions normally. It may lead to chronic chest pain.

Endothelial dysfunction is attributed to a decrease in levels of nitric oxide (NO) in the walls of blood vessels. Nitric oxide gas is formed by amino acid metabolism. It helps to regulate vascular tone and the other essential endothelial duties locally inside blood vessels. Deficiency in nitric oxide output leads to excess blood vessel compression (which may cause hypertension), corresponds to platelet activation (contributing to blood clotting), enhances the stimulation of inflammation in the walls of the blood vessels (which may lead to atherosclerosis), and raises the absorption of the vessel walls to harmful lipoproteins and different toxins. In short, endothelial dysfunction is associated with reduced levels of vascular nitric oxide. This, in turn, leads to many irregularities in the function of the blood vessels. These variations in function appear to promote heart disease.

A variety of conditions associated with rapid, decreased blood flow to the heart are defined as an acute coronary syndrome. The blockage may be abrupt and occur in one moment, or it may appear and go over a period of time. The disorder arises due to the accumulation of fatty deposits in and on the walls of the blood vessels. The function of these vessels is to supply nutrients and oxygen to the heart muscles. To function normally, the heart muscles require oxygen-rich blood. If the oxygen supply to these cells is too low, the heart muscle cells can also die. This may damage the muscle tissue, and cause a heart attack.

The PULS Test results include your overall PULS score or Cardiac Profile. It will also show the individual scores for every 9 protein biomarkers that lead to your aggregate 5-year dysfunctional cardiac lesion evaluation and risk of rupture. This score is then graded as normal (<3.5%), moderate (3.5-7.49 %), or elevated (>7.5%). You may also receive your "heart age" that shows your cardiac performance relative to your gender and age group, and recommended lifestyle improvements that can help to maintain or decrease the chances of a heart attack. This result aids the doctors to decide the patient's most suitable course of action on the basis of the recent clinical guidelines.

The PULS Cardiac Test is highly accurate in recognizing at-risk patients who are typically overlooked by other testing methods, such as plaque and cholesterol testing. This test can be used for both predictive and diagnostic purposes to widen the scope of patients identified with respect to acute coronary syndrome.

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The PULS Cardiac Test is a serum blood test that requires 1 SST and 1 Lavender tube of blood. Book your appointment for the test.

This test distinguishes patients who might not be considered at high risk, and also the patients who may have less chance of heart failure. It also ensures that only those patients who genuinely need the care are selected for intervention. The PULS Test identifies the initial stages of endothelial or arterial damage, diagnoses the stage of the disease, and determines how likely the condition may cause an abnormal cardiac lesion rupture. In addition,  It encourages patients to comply with guidelines from physicians.  The result helps to detect the patients prone to risk.  The test is validated on people of various ethnicities.  It adheres to the existing guidelines of ACC (American College of Cardiology) and AHA (American Heart Association).

The PULS Cardiac Test is tailored for patients 40 years of age or older with no known history of a heart attack. However, in the case of younger patients, the test may be determined by the clinical condition and medical requirements. For younger people, a baseline CHD assessment test is recommended as per the AHA guidelines, which includes elementary and expanded lipid profile assessment.

The cost of the PULS Test depends on various factors like place, technique, specialist, etc. For more information, feel free to contact us and we would be glad to assist you.